Faik Oruc¸oglu, MD, Eytan Z. Blumenthal, MD, Joseph Frucht-Pery, MD, and Abraham Solomon, MD

Journal of Glaucoma. 2013 Feb 19.
Kudret Eye Hospital, Istanbul, Turkey Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.


PURPOSE: Ocular hypertension is a potentially serious complication after penetrating keratoplasty (PKP). Our objective is to determine the risk factors, incidence, patient characteristics, response to pressure-lowering medical therapy, and graft outcome associated with elevation of intraocular pressure after PKP.

METHODS: One hundred forty-six consecutive eyes that had PKP between June 2001 and June 2003 were operated and managed at Hadassah-Hebrew University Medical Center. Chart review was performed seeking preoperative and postoperative data on risk factors for ocular hypertension after PKP. Univariate and logistic regression analysis were performed to identify significant risk factors.

RESULTS: After surgery, 70 eyes (47.9%) had at least 1 period of ocular hypertension, with a mean intraocular pressure (IOP) of 27.15+/-5.66 mm Hg. Ocular hypertension appeared after a mean postoperative period of 70.3+/-15.8 days, and continued for an average period of 15.6+/-2.0 days. In 35 eyes (23.9%), a second episode of IOP elevation was noted 212.2+/-46.8 days after the surgery. Logistic regression analysis revealed that preexisting glaucoma (P=0.009) and an additional surgical procedure combined with PKP (P=0.007) were the main factors predicting ocular hypertension after PKP. In 11 eyes (7.53%) the topical pressure-lowering therapy failed, and they required glaucoma filtering surgery.

CONCLUSION: The incidence of ocular hypertension after PKP is high, and at least 1 episode of high IOP was noted in almost half of our patients. A history of preexisting glaucoma and an additional surgical procedure combined with PKP were found to be significant factors predicting the occurrence of ocular hypertension.

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אתר זה נכתב ע”י פרופ’ איתן בלומנטל. באתר תמצאו אינפורמציה מעמיקה על האבחון והטיפול בגלאוקומה ובקטרקט. האינפורמציה באתר איננה תחליף לייעוץ רפואי.

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ORIGINAL RESEARCH PAPERS Blumenthal EZ. Adjusting the slit-lamp oculars: An unnecessary burden or a must?  Survey of Ophthalmology 1995;40(3):225-228. Abstract Full-text (PDF) Blumenthal EZ, Serpetopoulos...
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Adjusting The Slit-Lamp Oculars: An Unnecessary Burden Or A Must?
Blumenthal EZ. Surv Ophthalmol. 1995 Nov-Dec;40(3):225-8. Department of Opthalmology, Hadassah University Hospital, Jerusalem, Israel. ABSTRACT: Adjusting the slit-lamp eyepiece rings is perceived by some...
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On Focusing The Slit-Lamp: Part I. An Inaccurate Ocular Setting–What Is There To Lose?
Blumenthal EZ, Serpetopoulos CN. Surv Ophthalmol. 1998 Jan-Feb;42(4):351-4. Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel. ABSTRACT: Adjustments of the diopter rings on the...
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Glaucomatous-Like Cupping Associated With Slow-Growing Supra-Sellar Intracranial Lesions
Blumenthal EZ, Girkin CA, Dotan S. Neuro-Ophthalmology. 2006;30:111-115. Department of Ophthalmology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. eblumenthal@md.huji.ac.il ABSTRACT: PURPOSE:...
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On Focusing The Slit-Lamp: Part II. “The Fading-Slit Test” Verifying The Ocular Setting
Blumenthal EZ, Serpetopoulos CN Surv Ophthalmol. 1998 Jan-Feb;42(4):355-7. Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel. ABSTRACT The focusing-rod test is considered the...